Abstract:
Abstract
Back ground: The hematological abnormalities such as anemia, Leukocytopenia, leukocytosis, thrombocytopenia and thrombocytosis are commonly affecting individuals with type 2 DM with varied severity and magnitude which covers from 0.5 % (eosinophilia) to 30% (neutrophilia).
Objective: -The study mainly aimed to determine the magnitude and associated factors of hematological abnormality among Type 2 Diabetic adult patients at Mizan Tepi university teaching hospital, south west Ethiopia.
Methods: - Institutional based cross sectional study will be conducted on 356 Type 2 Diabetic adult patients at Mizan Tepi university teaching hospital from September to December 2023. Data for socio-demography, dietary and clinical data were collected by structured pretested questionnaire. About 5 ml of venous blood was drawn from each participant into EDTA test tube and analyzed by symiens ADVIA hematology analyzer for leukocyte, erythrocyte and platelate count. Blood film and stool examination were performed. Data was entered into Epi-data version 4.6 and analyzed by STATA statistical software version 14. Descriptive statistics and measure of association were computed for associated factors by multivariate logistic regression. The association was interpreted as p-value <0.05 to measure association.
Result; The overall magnitude of anemia, leukocytosis, thrombocytopenia and neutrophilia respectively were 40.35%, 57.7%, 16.5% and 48.66%. Determinant factors that shown significant association with anemia, leukocytosis, and thrombocytopenia were duration of DM greater than five year (2.14(95 % CI, 1.85, 2.27), Malaria infection (4.5(95 % CI, 4.30, 4.72)), birth interval greater than two year (1.45 (95 % CI, 1.25, 1.64)), third trimester gestational age (1.73 (95 % CI, 1.18, 2.31)), being overweight (3.0 (95 % CI, 2.52,3.49)).
Conclusion and recomendation
Hematological abnormalities especially anemia, and leukocytosis, were the major public health problem and thrombocytopenia was mild public health problem, among DM patients and shown significant association, duration of DM greater than five year, malaria infection, birth interval greater than two year, third trimester gestational age , and being underweight .So we recommend that DM patients should be checked their hematological parameters with continuous nutritional and life style modification, contraceptive to increase birth interval and use vegetables based diet.
